The unique global strong solution in the Chemin–Lerner type space to the Cauchy problem on the Boltzmann equation for hard potentials is constructed in a perturbation framework. Such a solution space is of critical regularity with respect to the spatial variable, and it can capture the intrinsic properties of the Boltzmann equation. For the proof of global well-posedness, we develop some new estimates on the nonlinear collision term through the Littlewood–Paley theory.